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Bio-Techne Releases A Highly Sensitive and Specific Serological Assay to Detect Zika Virus Infections

AAOMS issues opioid prescribing recommendations

New Review: Roles of Vitamins K2 & D for Children’s Bone Health

Released: 09/07/17

Bio-Techne Releases A Highly Sensitive and Specific Serological Assay to Detect Zika Virus Infections

R&D Systems®, a Bio-Techne brand, announced today the release of a new rapid, solid phase, enzyme-linked immunosorbent assay (ELISA) designed to measure anti-Zika virus immunoglobulin G (IgG) antibodies in human serum. A unique feature of this assay is that, prior to performing the test, samples are pre-treated with a proprietary reagent designed to minimize any interfering proteins present in the serum which could produce a false positive result. In-house testing demonstrates that this kit is highly sensitive to anti-Zika virus IgG and displays minimal cross-reactivity with dengue virus IgG antibodies.

R&D Systems® Anti-Zika Virus IgG ELISA Kit will benefit researchers that need an accurate serological method of detecting Zika virus infection in samples collected five or more days following the onset of symptoms. It will be particularly useful for researchers that are testing samples collected from areas where Zika virus and Dengue virus co-circulate since it is specifically designed to minimize interfering proteins that may be present in the serum. This ensures that the assay will clearly distinguish between Zika virus and Dengue virus and eliminates the likelihood of a false positive result due to a previous flavivirus infection or vaccination. Furthermore, since approximately 80% of the individuals infected with the Zika virus don't realize that they are infected and IgG antibodies persist for such a long time following infection, this kit can be used to detect prior infections and determine whether the Zika virus may be linked to subsequent neurological disorders or fetal abnormalities. 

To enable researchers to learn more about this new test, R&D Systems will be hosting an educational webinar describing how the test was developed, how it compares to other Zika virus tests, and best practices for its use in the laboratory setting. To learn more and to register for this webinar, please go to https://www.rndsystems.com/blog/emergence-zika-virus-and-methods-detection

Dave Eansor, Senior Vice President of Bio-Techne's Biotechnology Division, commented, "With the recent Zika virus outbreak, we recognize the need for more research dedicated to understanding the biology of emerging viruses. We are excited to contribute to this field by focusing on the development of new reagents for detecting viral infections and monitoring anti-viral immune responses." 

This assay is Bio-Techne's second innovative tool for Zika research, as it complements the RNAscope® assay for Zika virus detection available from Advanced Cell Diagnostics (ACD), a Bio-Techne brand.  This product also provides a robust and accurate method to detect low levels of viral RNA in virtually any tissue sample.  The ACD RNAscope® in situ hybridization technology preserves the morphology of infected tissues, enabling the detection of viral RNA in a morphological context.

For more information on Bio-Techne and its brands, please visit www.bio-techne.com


Released: 09/07/17

AAOMS issues opioid prescribing recommendations

In response to the nationwide opioid epidemic, the American Association of Oral and Maxillofacial Surgeons (AAOMS) released prescribing recommendations today that urge ibuprofen – rather than opioids – to be used as a first-line therapy to manage a patient's acute and post-surgical pain.

Recognizing the value and importance of the doctor-patient relationship, the AAOMS White Paper "Opioid Prescribing: Acute and Postoperative Pain Management" stresses that practitioners should be allowed to make individualized pain management decisions for their patients – including drug types, dosages and treatment durations.

If opioids are considered, AAOMS recommends doctors begin with the lowest possible effective dose for the shortest duration possible. Long-acting or extended-release opioids should be avoided as a starting treatment, the document advises. As an alternative, doctors are reminded that ibuprofen and acetaminophen – taken simultaneously – can rival opioids in their analgesic effect.

"Patient safety is the top priority of the American Association of Oral and Maxillofacial Surgeons," said AAOMS President Douglas W. Fain, DDS, MD, FACS. "Therefore, AAOMS has taken a leadership role in combatting the opioid epidemic afflicting this country. It is crucial for our doctors to responsibly prescribe based on individual patient needs and to use non-opioids when appropriate."

When using opioids to manage acute and post-surgical pain, it is recommended that doctors prescribe them safely and expertly, use the state's prescription-drug monitoring program, and inform patients and their families about opioids' potential risks as well as safe use, storage and disposal. Doctors also should remain aware of the most recent public health trends, including potential alternatives to opioids, the document advises.

The white paper recommendations are the work of a Special Committee on Opioid Prescribing appointed by the AAOMS Board of Trustees this spring.

"While oral and maxillofacial surgeons should ultimately make all final prescribing decisions, the recommendations in this AAOMS White Paper are intended to provide direction and serve as a supportive resource," the document states.

Among recommendations:

  • Prescribe non-steroidal anti-inflammatory drugs (NSAIDs, generically known as ibuprofen) as first-line pain-relief therapy, unless they are harmful to the patient. In that case, providers should prescribe acetaminophen.
  • Document dosage levels and times of administration of ibuprofen and acetaminophen taken simultaneously to prevent overdosage.
  • Inform patients not to exceed 3,200 milligrams of ibuprofen per day. In addition, the maximum recommended daily dose of acetaminophen is 3,000 milligrams.
  • Access the state's prescription drug-monitoring program or other resources if patient drug misuse is suspected.
  • Document all instructions for each patient's pain relief and prescriptions.
  • Document reasoning for not following these recommendations or those required by state laws or institutions. 
  • Consider using a corticosteroid during surgery to limit swelling and lower post-surgical discomfort after wisdom teeth removal.
  • Consider using a long-acting local anesthetic to postpone the onset and severity of post-surgical pain.

According to a 2017 AAOMS survey of its fellows and members, nearly 50 percent of respondents have decreased the number of narcotics they have prescribed for wisdom teeth extraction cases in the last two years. In addition, nearly 72 percent of respondents said they would refill a narcotic pain prescription only if they see the patient first.


The AAOMS white paper is available online at http://www.aaoms.org/docs/govt_affairs/advocacy_white_papers/opioid_prescribing.pdf.


Released: 09/07/17

New Review: Roles of Vitamins K2 & D for Children’s Bone Health

Evidence shows correcting deficiencies, specifically Vitamin K2, leads to stronger skeletal systems


OSLO, NORWAY and METUCHEN, NJ (September 7, 2017) – The Journal of the American College of Nutrition has published an important review paper that highlights the impact correcting nutritional insufficiencies, most importantly Vitamin K2 in combination with vitamin D and calcium, leading to a significantly less incidence of low-energy bone fractures in children and young adults.


According to Dr. Vladimir Badmaev, author of the paper and principal and founder of American Medical Holdings, Inc., “The epidemiological evidence indicates a disturbing growth in the number of cases of low-energy fractures in healthy children and adolescents. There are multiple risk factors that may contribute to this growing health concern, and deficient or insufficient nutrition and nutrients, including calcium, vitamin D and vitamin K are among leading considerations.”


Dr. Badmaev led an international research consortium with representatives in the United States and Poland to review the expansive body of research (epidemiological and human clinical) that shows environmental and nutritional factors that contribute to children’s bone health, the mechanisms and biological roles by which nutrients contribute to bone health in children and young adults, and the status of nutrient insufficiency and deficiency of these nutrients.


Badmaev explains that the the particular role of vitamin K2, especially menaquinone-7 (MK-7), has been highlighted in the literature recently and distinguished from vitamin K1 in maintaining calcium homeostasis and healthy skeletal system. “The epidemiological and clinical research provides a new nutritional paradigm for efficient and safe delivery of calcium that requires co-supplementation with both fat-soluble vitamins D and K.”


“This review is so very significant, providing supporting evidence to the clinical research NattoPharma has already spearheaded,” says Dr. Hogne Vik, chief medical officer with NattoPharma ASA, world leaders in vitamin K2 reseaerch and development. “Not only has our research identified children as a group most deficient in Vitamin K2, but that just 45mcg of K2 (as NattoPharma’s MenaQ7®) daily improves K status and increases the activation of osteocalcin, the K-dependent protein responsible for binding calcium to the bone mineral matrix, therefore improving bone health.”


Badmaev concludes, “The new proposed nutritional regimen may not only prevent low-energy fractures among children and young adults, but will also contribute to building the ‘bone bank’, therefore helping to prevent development of osteoporosis later in life and prevent untoward cardiovascular risk.”



Karpinski M, Popko J, Maresz K, Badmaev V, Stohs SJ. Roles of Vitamins D and K, Nutrition, and Lifestyle

in Low-Energy Bone Fractures in Children and Young Adults. J Am Coll Nutr. 017 Jul;36(5):399-4012. Doi: 10.1080/07315724.2017.1307791.



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About NattoPharma and MenaQ7®

NattoPharma ASA, based in Norway, is the world’s leader in vitamin K2 research and development. NattoPharma is the exclusive international supplier of MenaQ7® Vitamin K2 as MK-7, the best documented, vitamin K2 as menaquinone-7 (MK-7) with guaranteed actives and stability, clinical substantiation, and


international patents granted and pending. The company has a multi-year research and development program to substantiate and discover the health benefits of vitamin K2 for applications in the marketplace for functional food and dietary supplements. With a global presence, the company established its North American subsidiary, NattoPharma USA, Inc., in Metuchen, NJ, and NattoPharma R&D Ltd. in Cyprus. For more information, visit www.nattopharma.com or www.menaq7.com.


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