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April, 2014 - VOL. 13, NO. 2  April, 2014
Mitochondria—Fundamental to Life and Health
Joseph Pizzorno, ND
In the past few years, I have become progressively more aware of the foundational importance of optimal mitochondrial function for health and the growing body of research showing that dysfunction is surprisingly common and associated with most chronic disease. In my IMCJ 12.5 editorial, Lara and I presented helpful clinical pearls on mitochondrial health from the Institute of Functional Medicine conference in Dallas last spring. In my IMCJ 13.1 editorial, I stated that glutathione is “… vital to mitochondrial function and maintenance of mitochondrial DNA (mtDNA).” I have found the mitochondrial connection to health so interesting and important that I have now developed a 90-minute lecture on the topic and think the time has come for an editorial. As illustrated in Table 1, with such a long list of common diseases now caused by or aggravated by mitochondrial dysfunction, it is difficult to overstate its importance.
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April, 2014 - VOL. 13, NO. 2  April, 2014
Institute for Integrative Health in $1-Million Grant to Explore Nature’s Effect on Wounded Warriors … plus more
John Weeks
The Institute for Integrative Health (TIIH), led by Brian Berman, MD, and Sue Berman, has received a $1-million grant from the TKF Foundation “to create an outdoor healing space and study its impact on wounded warriors who spend time there.” Titled the Green Road Project, the initiative will “turn a swath of woodland into an oasis of respite on the campus of Naval Support Activity Bethesda, home of Walter Reed National Military Medical Center.”1 States Berman: “While helping service members and their families restore their bodies, minds and spirits, the Green Road Project aims to expand the evidence base for using the natural environment as a tool for healing.” Fred Foote, MD, is the TIIH scholar who conceived the Green Road Project. He notes that “holistic therapies, such as art-making and encounters with nature, aren’t fully accepted because scientists haven’t had a way to measure their effects, but that’s changing.” He expects that by 2016, the team will have “prove[d] by direct measurement that exposure to nature can heal the human body.” The project’s collaborators include (1) Consortium for Health and Military Performance at the Uniformed Services University of the Health Sciences (Department of Defense), (2) NIH Clinical Center’s Pain and Palliative Care Service, and (3) the University of Arizona Institute for Place and Wellbeing.
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April, 2014 - VOL. 13, NO. 2  April, 2014
Presenters 2014: Michael Greger, MD: Reversing Chronic Disease Through Diet; Addressing the 2015 USDA Dietary Guidelines Committee
Craig Gustafson
Michael Greger, MD, will be the keynote speaker at the 2014 American Association of Naturopathic Physicians (AANP) Conference scheduled for August 6-9 in Phoenix, Arizona. Dr Greger is a founding member of the American College of Lifestyle Medicine, author, and internationally recognized speaker on nutrition, food safety, and public health issues. He has lectured at the Conference on World Affairs, testified before Congress, appeared on The Dr Oz Show and The Colbert Report, and was invited as an expert witness in the defense of Oprah Winfrey in the infamous “meat defamation” trial. He is a graduate of Cornell University School of Agriculture and Tufts University School of Medicine. Currently Dr Greger serves as the Director of Public Health and Animal Agriculture at The Humane Society of the United States. His nutrition work is available at his nonprofit Web site http://www.NutritionFacts.org.
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April, 2014 - VOL. 13, NO. 2  April, 2014
A Randomized, Controlled Pilot Study of the Effects of Acupuncture on Circulating Endothelial Progenitor Cells in Coronary Heart Disease
C. Noel Bairey Merz, MD;  Anna Brantman, DAOM, LAc;  Supurna Chowdhury, MS;  Shivani Dhawan, MS;  Ning Li, PhD;  Xiuling Ma, PhD, LAc;  Puja Mehta, MD;  Jeannette Painovich, DAOM, LAc;  Anita Phancao, MD;  Yi Qiao, LAc;  Doris Taylor, PhD
Context: Coronary heart disease (CHD) remains the number one killer of men and women in the United States, and despite traditional secondary prevention, individuals with the disease remain at risk. Endothelial progenitor cells (EPCs) may have beneficial effects on atherosclerosis, angiogenesis, and vascular repair and may contribute systemically to ongoing endogenous repair processes. Traditional acupuncture (TA), a modality used in the practice of Chinese medicine, appears to have beneficial effects in many areas associated with CHD. Objective: The study examined the effects of TA on circulating EPCs in individuals with CHD. Design: The research team performed a randomized, controlled pilot study. Setting: All interventions were performed at the Cedars-Sinai Medical Center in Los Angeles, CA. Participants: The study included 13 participants in 3 groups: (1) TA (n = 5), (2) sham acupuncture (SA, n = 5), or (3) waiting control (WC, n = 3). Intervention: The TA group received acupuncture treatments for 12 wk at CHD-specific sites, while the SA group received no-needle pressure at nonacupuncture sites for the same period, and the WC group received no intervention. Outcome Measures: The study measured the number of EPCs circulating in peripheral blood to determine cell surface markers for expressions of cluster of differentiation 34, 133 (CD34+/CD133+) and vascular endothelial growth factor receptor 2 (VEGF-R2+). Results: Eight men and 5 women with a mean age of 59 ± 10.9 y were included. Compared with their measurements at baseline, members of the TA group had a significantly greater change in the level of EPCs expressing CD34+/VEGF-R2+ compared with the SA group (P = .04). No group differences were evident in immature EPCs expressing CD34+/CD133+. Conclusion: The study’s results suggest that TA can alter the number of EPCs circulating in peripheral blood by increasing the mobilization of the VEGF-R2+ EPC subpopulations. Further studies are warranted to evaluate whether TA can beneficially affect CHD via augmentation of EPC regenerative pathways.
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April, 2014 - VOL. 13, NO. 2  April, 2014
Conventional Practitioners’ Communication of Integrative Alternatives for Chronic Back Pain: An Evidence-based, Patient-centered Model
Ruthann Russo, PhD, JD, MPH, LAc
Chronic back pain is one of the most common conditions treated in the United States. Informed consent is the communication of treatment alternatives, benefits, and risks and must be provided to patients in most instances. The alternatives provided during this discussion should include all options supported by research evidence and the patient’s preferences. This article proposes a model for chronic back pain that includes the communication of complementary therapies as part of a patient-centered, integrative approach to informed consent. The content of informed consent is determined by common law (court cases), legislation, regulations, and evidence-based research. The practitioner’s and patient’s knowledge and the patient’s values should be used to filter this information. Finally, shared decision making should be used to arrive at the patient’s final decision regarding informed consent for treatment.
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April, 2014 - VOL. 13, NO. 2  April, 2014
Escharotic Treatment for ECC-positive CIN3 in Childbearing Years: A Case Report
Corina Dunlap, BA;  Kimberly Windstar, MEd, ND;  Heather Zwickey, PhD
A persistent human papillomavirus (HPV) infection of a high-risk type is necessary for cervical cancer to develop. The severity of the diagnosis, together with colposcopy findings, determines the standard for treatment, and ablative or excisional options may be recommended. Escharotic treatment, together with an oral, anticarcinogenic HPV protocol and a vaginal-suppository protocol, is an alternative treatment, especially for those women of childbearing age who are concerned about the possibility of obstetrical complications associated with the use of loop electrosurgical excision (LEEP). The aim of the current case study was to observe the effect of an ablative escharotic treatment for a woman with severe dysplasia, cervical intraepithelial neoplasia grade 3 (CIN3). A 28-y-old female visited the National College of Natural Medicine clinic to obtain suggestions for alternative treatments following a satisfactory colposcopy and a biopsy revealing a high-risk HPV effect, severe dysplasia CIN3, and a positive endocervical curettage (ECC). She refused the recommended standard of care, a LEEP, because of concerns about the potential for future obstetrical complications. As an alternative, she elected to receive an escharotic treatment at a frequency of 2 treatments/wk for 5 wk. In addition to the escharotic treatment, she followed an oral protocol consisting of vitamins and botanical medicine for 1 y and she completed a 12-wk regime of vaginal suppositories following the escharotic. The authors followed her for 2 y. The woman’s Papanicolaou (Pap) test at the 6-mo follow-up revealed negative cervical cytology for intraepithelial lesion or malignancy, and her follow-up ECC was negative. Liquid-based Pap results were normal, and HPV testing was negative at her 1-y follow-up. Her Pap continued to remain normal at her 2-y follow-up. For women with high-grade cervical neoplasias and positive ECCs, with satisfactory colposcopies, escharotic treatment, accompanied by oral supplementation, holds promise as an effective alternative to LEEP and other excisional procedures.
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April, 2014 - VOL. 13, NO. 2  April, 2014
Sarah Speck, MD, and Daniel Tripps, PhD: A New Integrative Cardiology Model
Craig Gustafson
Sarah M. Speck, MD, MPH, FACC, is CEO and medical director of Speck Health in Seattle, Washington. She is the medical director of the cardiac wellness and rehabilitation programs at the Swedish Heart and Vascular Institute in Seattle. She graduated from the University of Illinois with a combined MD/MPH and did her postgraduate medical training at the University of Washington Hospitals. She has always believed that preventing illness is the best approach to managing health and maintaining vitality at whatever stage of life. In 2009 she cofounded POTENTRx, a medical fitness company, to offer patients a medically supervised lifestyle approach to health. She is an expert educator for fellow professionals in illness prevention, disease reversal, and disease management techniques. She believes that partnering with her patients offers the best possible avenue to improving and maintaining their health. Dan G. Tripps, PhD, has been a coach for world-class swimmers and triathletes, president and executive director of the 1984 Olympic Scientific Congress held in conjunction with the Los Angeles Olympic Games, US representative to UNESCO’s Sport For All project to bring sport science to the developing world, and recently retired as director of the Center for the Study of Sport & Exercise at Seattle University, ending 35 years of academic life. Dr Tripps has written dozens of professional articles, addressed numerous conferences, and serves as a consultant to sport, medical, education, and private agencies on topics related to achievement and human performance. He has served as coeditor for 10 books on the subject of human performance and authored 2 of his own books.
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April, 2014 - VOL. 13, NO. 2  April, 2014
BackTalk: American Idolatry
Bill Benda, MD
I received an e-mail the other day from one of our integrative “personalities” who we see on conference brochures every month or two. It went something like this: Dear Bill — I’ve missed you! Hope your family is well! I have an exciting new book out, Bill, that I’d like to tell you about. I know you will be anxious to read it as soon as possible because I am using your actual first name and that means we are best friends! It’s called Dr Curzall’s Paleolithic Labrador Retriever Diet for Total Health and Sexual Prowess. Bill, I can’t begin to tell you how 2 meals a day of raw hamburger, kibble, and a tennis ball have made me a new man! Not to mention my wife! And if you act now, Bill, I’ll throw in my wildly popular newsletter, “Why I’m Rich and You’re Not.” It will change your life! I bought the book for my dog.
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